Details of the Approved Research Project
Approved Application Reference Number:
173546
Approved Application Name:
Revisiting polygenic scores in the gene-environment models for diseases
Applicant PI Name:
Professor Jakub Hlavka
Applicant Institution Name:
Masaryk University
Contact Details:
jakub.hlavka@econ.muni.cz
Health Economics, Policy and Innovation Institute
Masaryk University
Brno
Czech Republic
Czechia
Approved Research Project Scope
The approved project scope for this application is:
Given the complexity of genetic data, researchers often condense genetic predispositions for specific traits using polygenic scores (PGS). These scores leverage summary statistics obtained from genome-wide association studies (GWAS) to establish a weighted aggregate of all risky genetic variants that an individual carries. Despite the widespread utilization of PGS in empirical analyses, they do suffer from several limitations and deficiencies.
First, we aim to show that the current methods of PGS construction lead to measurement error bias in the gene-environment studies. Second, in an effort to overcome these limitations, we aim to refine the current gene-enviornment models within a sample-splitting framework, and derive a new set of weights that can be used in polygenic scores and do not lead to measurement error bias in the gene-environment models.
Finally, we plan to apply our new two-step approach and explore the intricate interplay between genes and the environment in shaping important health outcomes including heart attack, cancer, strokes, obesity, and blood pressure. Moreover, we aim to investigate the channels through which environment anf genes affect these outcomes. For that purpose we also plan to examine phenotypes concerning lifestyle such as accelerometer results and dietary habbits.
Timeframe
Project start date:
Not yet started
Current project duration:
36 month(s)
Current project end-date:
Materials
Access Charges
Please refer to your invoice(s) for specific details of the Access Charges applicable to your Approved Research Project.
Specific Conditions
Project approved for 12 month duration only and not 36 months. Adjustment of duration to be completed upon date of project started.
Access Sub-Committee additional comments: None.
Collaborators
Researchers that are working in collaboration with the Applicant PI and
that will have direct access to the Materials must apply to UK Biobank under
the Access Procedures and enter into an MTA with UK Biobank.
The current details of Collaborators are provided below.
Further Collaborators can be added by the Applicant, subject to
application to UK Biobank and to the provisions of the Access Procedures, at any time.
The current list of Collaborators:
Collaborators at institutes with executed MTAs:
Collaborators at institutes that do not yet have executed MTAs:
Applicant PI Name:
Professor Jakub Hlavka
Contact Details:
jakub.hlavka@econ.muni.cz
Health Economics, Policy and Innovation Institute
Masaryk University
Brno
Czech Republic
Czechia
Collaborator Name:
Mr Jaroslav Groero
Contact Details:
Jaroslav.Groero@econ.muni.cz
Health Economics, Policy and Innovation Institute
Masaryk University
Brno
Czech Republic
Czechia
Collaborator Name:
Miss Tereza Skyvarova
Contact Details:
495055@mail.muni.cz
Masaryk University
Brno
Czech Republic
Czechia
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